Product Name :
Duocarmycin MA
Description:
Duocarmycin MA is an antibody drug conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove. Duocarmycin MA can be used against multi-drug resistant cell lines.
CAS:
1613286-57-9
Molecular Weight:
611.09
Formula:
C34H31ClN4O5
Chemical Name:
tert-butyl N-[4-({2-[(1S)-1-(chloromethyl)-5-hydroxy-1H, 2H, 3H-benzo[e]indole-3-carbonyl]-1H-indol-6-yl}carbamoyl)phenyl]carbamate
Smiles :
CC(C)(C)OC(=O)NC1C=CC(=CC=1)C(=O)NC1=CC2NC(=CC=2C=C1)C(=O)N1C[C@@H](CCl)C2C3=CC=CC=C3C(O)=CC1=2
InChiKey:
MZXQBIDDBQCHFP-OAQYLSRUSA-N
InChi :
InChI=1S/C34H31ClN4O5/c1-34(2,3)44-33(43)37-22-11-8-19(9-12-22)31(41)36-23-13-10-20-14-27(38-26(20)15-23)32(42)39-18-21(17-35)30-25-7-5-4-6-24(25)29(40)16-28(30)39/h4-16,21,38,40H,17-18H2,1-3H3,(H,36,41)(H,37,43)/t21-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Chamaejasmenin A} web|{Chamaejasmenin A} Immunology/Inflammation|{Chamaejasmenin A} Technical Information|{Chamaejasmenin A} Description|{Chamaejasmenin A} manufacturer|{Chamaejasmenin A} Cancer}
Shelf Life:
≥360 days if stored properly.{{Leflunomide} site|{Leflunomide} Metabolic Enzyme/Protease|{Leflunomide} Protocol|{Leflunomide} References|{Leflunomide} custom synthesis|{Leflunomide} Epigenetics}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32032230
Additional information:
Duocarmycin MA is an antibody drug conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove. Duocarmycin MA can be used against multi-drug resistant cell lines.|Product information|CAS Number: 1613286-57-9|Molecular Weight: 611.09|Formula: C34H31ClN4O5|Chemical Name: tert-butyl N-[4-({2-[(1S)-1-(chloromethyl)-5-hydroxy-1H, 2H, 3H-benzo[e]indole-3-carbonyl]-1H-indol-6-yl}carbamoyl)phenyl]carbamate|Smiles: CC(C)(C)OC(=O)NC1C=CC(=CC=1)C(=O)NC1=CC2NC(=CC=2C=C1)C(=O)N1C[C@@H](CCl)C2C3=CC=CC=C3C(O)=CC1=2|InChiKey: MZXQBIDDBQCHFP-OAQYLSRUSA-N|InChi: InChI=1S/C34H31ClN4O5/c1-34(2,3)44-33(43)37-22-11-8-19(9-12-22)31(41)36-23-13-10-20-14-27(38-26(20)15-23)32(42)39-18-21(17-35)30-25-7-5-4-6-24(25)29(40)16-28(30)39/h4-16,21,38,40H,17-18H2,1-3H3,(H,36,41)(H,37,43)/t21-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Searcey M. Duocarmycins–natures prodrugs? Curr Pharm Des. 2002;8(15):1375-89.Products are for research use only. Not for human use.|