The histone deacetylase SIRT6 regulates glucose homeostasis by suppressing the exercise of HIF-1a. By rising HIF-1a, SIRT6 deficiency benefits not only in improved expression of PDK1 and several glycolytic genes but also in enhanced expression of PDK4 [23]

Previous studies have proven that ERRb is a constructive and vital ingredient of the HIF transcriptional complexes that handle hypoxia inducible gene expression. ERRa and ERRb serve as crucial cofactors…