Product Name :
PF-3758309

Description:
PF-3758309, also known as PF-03758309, is a PAK4 inhibitor, is also a n orally bioavailable small-molecule inhibitor of p21-activated kinase 4 (PAK4) with potential antineoplastic activity. PAK4 inhibitor PF-03758309 binds to PAK4, inhibiting PAK4 activity and cancer cell growth. PAK4, a serine/threonine kinase belonging to the p21-activated kinase (PAK) family, is often upregulated in a variety of cancer cell types and plays an important role in cancer cell motility, proliferation, and survival.

CAS:
898044-15-0

Molecular Weight:
490.62

Formula:
C25H30N8OS

Chemical Name:
N-[(1S)-2-(dimethylamino)-1-phenylethyl]-6,6-dimethyl-3-({2-methylthieno[3,2-d]pyrimidin-4-yl}amino)-1H,4H,5H,6H-pyrrolo[3,4-c]pyrazole-5-carboxamide

Smiles :
CN(C)C[C@@H](NC(=O)N1CC2C(NC3=NC(C)=NC4C=CSC=43)=NNC=2C1(C)C)C1C=CC=CC=1

InChiKey:
AYCPARAPKDAOEN-LJQANCHMSA-N

InChi :
InChI=1S/C25H30N8OS/c1-15-26-18-11-12-35-20(18)23(27-15)29-22-17-13-33(25(2,3)21(17)30-31-22)24(34)28-19(14-32(4)5)16-9-7-6-8-10-16/h6-12,19H,13-14H2,1-5H3,(H,28,34)(H2,26,27,29,30,31)/t19-/m1/s1

Purity:
≥98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Dodecyltrimethylammonium} site|{Dodecyltrimethylammonium} {Biochemical Assay Reagents}|{Dodecyltrimethylammonium} Protocol|{Dodecyltrimethylammonium} Purity|{Dodecyltrimethylammonium} manufacturer|{Dodecyltrimethylammonium} Epigenetics}

Shelf Life:
≥360 days if stored properly.{{Flubendazole} web|{Flubendazole} Stem Cell/Wnt|{Flubendazole} Purity & Documentation|{Flubendazole} In Vitro|{Flubendazole} supplier|{Flubendazole} Autophagy}

Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:28440459

Additional information:
PF-3758309, also known as PF-03758309, is a PAK4 inhibitor, is also a n orally bioavailable small-molecule inhibitor of p21-activated kinase 4 (PAK4) with potential antineoplastic activity. PAK4 inhibitor PF-03758309 binds to PAK4, inhibiting PAK4 activity and cancer cell growth. PAK4, a serine/threonine kinase belonging to the p21-activated kinase (PAK) family, is often upregulated in a variety of cancer cell types and plays an important role in cancer cell motility, proliferation, and survival.|Product information|CAS Number: 898044-15-0|Molecular Weight: 490.62|Formula: C25H30N8OS|Chemical Name: N-[(1S)-2-(dimethylamino)-1-phenylethyl]-6,6-dimethyl-3-({2-methylthieno[3,2-d]pyrimidin-4-yl}amino)-1H,4H,5H,6H-pyrrolo[3,4-c]pyrazole-5-carboxamide|Smiles: CN(C)C[C@@H](NC(=O)N1CC2C(NC3=NC(C)=NC4C=CSC=43)=NNC=2C1(C)C)C1C=CC=CC=1|InChiKey: AYCPARAPKDAOEN-LJQANCHMSA-N|InChi: InChI=1S/C25H30N8OS/c1-15-26-18-11-12-35-20(18)23(27-15)29-22-17-13-33(25(2,3)21(17)30-31-22)24(34)28-19(14-32(4)5)16-9-7-6-8-10-16/h6-12,19H,13-14H2,1-5H3,(H,28,34)(H2,26,27,29,30,31)/t19-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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