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Cannabis is the most widely applied illicit drug inside the world, and prevalence rates of cannabis use disorders are somewhat larger worldwide than for other drugs of abuse (UNODC, 2011). Cannabis withdrawal is prevalent amongst common customers attempting to quit or lower their use (Cornelius et al., 2008; Hasin et al., 2008) and withdrawal can be a strong motivator to continue employing marijuana, contributing to early relapse (Allsop et al., 2012; Budney et al., 2008). Conversely, reduction in withdrawal symptoms is linked with optimistic clinical outcomes in randomized-controlled trials: men and women getting gabapentin had attenuated withdrawal and reduced marijuana use (Mason et al., 2012), and folks treated with dronabinol had decreased withdrawal and increased study retention (Levin et al., 2011). We previously reported on a 12-week randomized controlled trial of venlafaxine-XR (VENXR) for comorbid cannabis dependence and depression, and found that participants getting 5-HT3 Receptor site VEN-XR had been significantly significantly less most likely to attain abstinence than individuals getting placebo, in spite of their depression enhancing (Levin et al., 2013). The findings of far more marijuana smoking in the VEN-XR group were unexpected, and prompted us to consider the role of withdrawal symptoms. Since men and women receiving VEN-XR didn’t significantly lower their smoking behavior, they wouldn’t be anticipated to practical experience extra serious cannabis withdrawal. However, we speculated that the overlap in the symptom profiles of cannabis withdrawal and VEN-XR unwanted side effects contributed to a higher burden of withdrawal-like sympt.