Graphica Section EStructure Reports OnlineISSN 1600-Triclinic, P1 a = 7.2573 (11) A b = ten.1538 (15) A c = 13.665 (two) A = 94.467 (3) = 99.120 (four)= 95.850 (4)V = 984.5 (3) A3 Z=4 Mo K radiation = 0.50 mm T = 273 K 0.37 0.15 0.11 mm3,4-Dimethylthieno[2,3-b]thiophene-2,5dicarbonitrileYahia Nasser Mabkhot,a S. S. Al-Showiman,a Assem Barakat,a,b M. Iqbal Choudharyc,a and Sammer YousufcDepartment of Chemistry, College of Science, King Saud University, PO Box 2455, Riyadh 11451, Saudi Arabia, bDepartment of Chemistry, Faculty of Science, Alexandria University, PO Box 426, Ibrahimia- 21321 Alexandria, Egypt, and cH.E.J. Study Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan Correspondence e-mail: dr.sammer.yousuf@gmail Received 24 June 2013; accepted 29 June 2013 Important indicators: single-crystal X-ray study; T = 273 K; imply (C ) = 0.004 A; R SIRT3 site factor = 0.055; wR factor = 0.132; data-to-parameter ratio = 19.1.aData collectionBruker Intelligent APEX CCD areadetector diffractometer Absorption correction: multi-scan (SADABS; Bruker, 2000) Tmin = 0.838, Tmax = 0.947 13821 measured reflections 4912 independent reflections 3074 reflections with I 2(I) Rint = 0.RefinementR[F 2 two(F 2)] = 0.055 wR(F two) = 0.132 S = 0.99 4912 reflections 257 parameters H-atom parameters constrained ax = 0.37 e A in = .24 e AThe asymmetric unit of your title compound, C10H6N2S2, consists of two crystallographically independent but conformationally similar molecules. The fused thiophene ring cores are almost planar [maximum deviation = 0.027 (three) A] together with the thiophene rings forming dihedral angles of 0.five (four) in one particular molecule and 1.91 (four) within the other. The crystal packing is stabilized only by van der Waals interactions.Information collection: Smart (Bruker, 2000); cell refinement: SAINT (Bruker, 2000); data reduction: SAINT; plan(s) applied to resolve structure: SHELXS97 (Sheldrick, 2008); system(s) applied to refine structure: SHELXL97 (Sheldrick, 2008); molecular graphics: SHELXTL (Sheldrick, 2008); software employed to prepare material for publication: SHELXTL, PARST (Nardelli, 1995) and PLATON (Spek, 2009).The authors extend their appreciation to the Deanship of Scientific Research in the King Saud University (Riyadh) for IRE1 list funding this study by means of the research grant No. RGP-VPP007.Supplementary information and figures for this paper are readily available from the IUCr electronic archives (Reference: RZ5077).Related literatureFor the biological activity of thiophene derivatives, see: Mabkhot et al. (2013); Mishra et al. (2011). For the synthesis of fused heterocyclic compounds, see: Cornel Kirsch (2001); Mashraqui et al. (1999). For crystal information for connected thiophene compounds, see: Gunasekaran et al. (2009); Mashraqui et al. (2004).
Pancreatic ductal adenocarcinoma (PDAC) lists amongst probably the most deadly kind of cancers [1]. Early-stage from the disease is clinically silent plus the diagnosis in the illness is mainly produced at an advanced stage. This late diagnosis contributes to one of several lowest 5-year survival price (only three ) [2]. Today PDAC are treated by surgery and/or adjuvant therapy with gemcitabine, increasing only slightly the median survival in the sufferers. There’s consequently an urgent need to develop new productive therapies for PDAC sufferers. You’ll find abundant evidence indicating that deregulation of histone acetylation contributes to pancreas cancer development and progression [3]. Histone deacetylases (HDAC) represent.