A mild antiproliferative activity by themselves, on the other hand synergizing strongly with LC, reaching a CI equal to 0.13 against LNCaP cells (whilst BC combined with LC resulted inside a CI of 0.65) [71]. Administered collectively using the traditional chemotherapeutics doxorubicin and temozolomide, lutein exerted some synergistic impact. However, it didn’t change the effectiveness of paclitaxel, 15dPGJ2 , pioglitazone and c-Jun N-terminal kinase 2 (JNK2) Proteins Species ciglitazone. An amount of 10 of lutein induced changes inside the amount of various proteins, causing a greater than 2-fold enhance in KLK8, IGF-2, TGF-3, at the same time as NR5A2 and simultaneously a 3-fold decrease in KLK14, KLK15, fibroblast growth factor 7 (FGF7), MAPK15, NR0B2 and PTEN [96]. Both proliferation stimulating and proliferation inhibiting proteins changed their levels. Aside from the truth that reasonably high concentrations of this agent decreased cellular