Rice is a fundamental staple crop, feeding over half the global population. However, its yield is severely threatened by abiotic stresses such as drought and salinity. Transcription factors (TFs), which…
**Background** The Asialoglycoprotein receptor (ASGPR) is a multifunctional endocytic receptor predominantly expressed on the sinusoidal surface of hepatocytes. It plays a critical role in the clearance of desialylated glycoproteins from…
The phosphoinositide 3-kinase (PI3K) and Akt signaling pathway plays a central role in regulating multiple cellular processes that drive cancer progression, particularly in breast cancer. Akt, a key downstream effector…
**Background** Mycobacterial infections, including tuberculosis and leprosy, remain significant global health challenges due to the high resistance of these pathogens to conventional therapies. Mycobacterium tuberculosis, M. leprae, and M. avium…
The generation of high-yield, functional polyclonal antibodies from sheep remains a critical goal for the development of passive immunotherapies against infectious diseases such as influenza. This study presents an empirical…
During the past decade, the development of nuclear spin polarization enhanced (hyperpolarized) molecular probes has revolutionized real-time studies of living cells. These probes are generated ex situ, introduced into biological…
**Background** Phospholipase A2 (PLA2) enzymes play a critical role in the hydrolysis of phospholipids, releasing arachidonic acid and contributing to various inflammatory and signaling pathways. Dysregulation of these pathways is…
Activation of inflammatory pathways in the endothelium is a key driver in vascular diseases such as sepsis and atherosclerosis. This study demonstrates that miR-146a and miR-146b are rapidly induced in…
**Background** Hepatitis C virus (HCV) is a major cause of chronic liver disease, cirrhosis, and hepatocellular carcinoma worldwide. The replication of HCV relies on several non-structural proteins, among which the…
Maternal metabolic disturbances during pregnancy have emerged as significant contributors to congenital heart disease (CHD), a leading cause of infant mortality worldwide. Recent clinical and experimental evidence implicates dysregulated fatty…