Rticipated within the design and style of the study and performed the statistical evaluation. PR and OB conceived with the study, and participated in its coordination. HC, JC, SM and OB contributed to the draft manuscript. OF, PB,References 1. WHO: World malaria report 2010. Geneva: World Overall health Organization; 2010. two. Globe Overall health Organization Regional Workplace for Europe: Centralized info method for infectious ailments (CISID). three. French Institute of Public Overall health, InVS: French national reference centre for malaria – Report 2011. Saint-Maurice, France: French Institute of Public Overall health, InVS; 2012:79. four. Bouchaud O, Muehlberger N, Parola P, Calleri G, Matteelli A, Peyerl-Hoffmann G, MechaF, Gautret P, Clerinx J, Kremsner PG, Jelinek T, Kaiser A, Beltrame A, Schmid M, Kern P, Probst M, Bartoloni A, Weinke T, Grobusch MP: Therapy of uncomplicated falciparum malaria in Europe: MALTHER – a prospective observational multicentre study. Malar J 2012, 11:212. 5. Soci de Pathologie Infectieuse de Langue Fran ise: Management and prevention of imported Plasmodium falciparum malaria (Revision 2007 in the 1999 Consensus Conference) (in French). Med Mal Infect 2008, 38:6817. six. Hudson AT: Lapinone, menoctone, hydroxynaphtoquinones and related structures. In Handbook of experimental pharmacology, antimalarial drugs. Edited by Peters WRW. Berlin – Heidelberg: Springer Verlag; 1984:34361. 7. Hudson AT, Randall AW, Fry M, Ginger CD, Hill B, Latter VS, McHardy N, Williams RB: Novel anti-malarial hydroxynaphthoquinones with potent broad spectrum anti-protozoal activity. Parasitology 1985, 90:455. eight. Gutteridge WE: Chemotherapy. In Modern parasitology. Edited by FG C. Oxford: Blackwell Scientific Publications; 1993:21839. 9. Chiodini PL, Conlon CP, Hutchinson DB, Farquhar JA, Hall AP, Peto TE, Birley H, Warrell DA: Evaluation of atovaquone in the remedy of sufferers with uncomplicated Plasmodium falciparum malaria.Pramipexole dihydrochloride J Antimicrob Chemother 1995, 36:1073078. ten. Bustos DG, Canfield CJ, Canete-Miguel E, Hutchinson DB: Atovaquone-proguanil compared with chloroquine and chloroquine-sulfadoxine-pyrimethamine for remedy of acute Plasmodium falciparum malaria within the Philippines. J Infect Dis 1999, 179:1587590.Camizestrant 11.PMID:25147652 De Alencar FE, Cerutti C, Durlacher RR, Boulos M, Alves FP, Milhous W, Pang LW: Atovaquone and proguanil for the therapy of malaria in Brazil. J Infect Dis 1997, 175:1544547. 12. Looareesuwan S, Wilairatana P, Chalermarut K, Rattanapong Y, Canfield CJ, Hutchinson DB: Efficacy and security of atovaquone/proguanil compared with mefloquine for remedy of acute Plasmodium falciparum malaria in Thailand. Am J Trop Med Hyg 1999, 60:52632. 13. Mulenga M, Sukwa TY, Canfield CJ, Hutchinson DB: Atovaquone and proguanil versus pyrimethamine/sulfadoxine for the treatment of acute falciparum malaria in Zambia. Clin Ther 1999, 21:84152. 14. Radloff PD, Philipps J, Nkeyi M, Hutchinson D, Kremsner PG: Atovaquone and proguanil for Plasmodium falciparum malaria. Lancet 1996, 347:1511514. 15. Bouchaud O, Monlun E, Muanza K, Fontanet A, Scott T, Goetschel A, Chulay JD, Le Bras J, Danis M, Le Bras M, Coulaud JP, Gentilini M: Atovaquone plus proguanil versus halofantrine for the therapy of imported acute uncomplicated Plasmodium falciparum malaria inCordel et al. Malaria Journal 2013, 12:399 http://www.malariajournal/content/12/1/Page 9 of16.17.18.19.20.21.22.23.24.25. 26.27.28.29.30. 31.32. 33.non-immune adults: a randomized comparative trial. Am J Trop Med Hyg 2000, 63:27479. Hi.