Ahani T, Entertaining HK, Venkat Ragavan R, Vijayakumar V, Sarveswari S (2010) 5-Ethyl-4-methyl-1H-pyrazol-3(2H)-one. Acta Cryst E66:o135773. Rathore RS, Narasimhamurthy T, Venkat Ragavan R, Vijayakumar V, Sarveswari S (2011) 3-Ethyl-4-methyl-1H-pyrazol-2-ium-5-olate. Acta Cryst E67:o2129 74. Loh WS, Enjoyable HK, Venkat Ragavan R, Vijayakumar V, Venkatesh M (2011) 5-Ethyl-4-phenyl-1H-pyrazol-3(2H)-one. Acta Cryst E67:o403 404 75. Shahani T, Enjoyable HK, Venkat Ragavan R, Vijayakumar V, Sarveswari S (2010) 5-Cyclohexyl-4-methyl-1H-pyrazol-3(2H)-one monohydrate. Acta Cryst E66:o2760doi:10.1186/2191-2858-3-6 Cite this short article as: Ragavan et al.: -Keto esters from ketones and ethyl chloroformate: a fast, basic, effective synthesis of pyrazolones and their antimicrobial, in silico and in vitro cytotoxicity studies. Organic and Medicinal Chemistry Letters 2013 3:6.Submit your manuscript to a journal and advantage from:7 Hassle-free on the web submission 7 Rigorous peer critique 7 Quick publication on acceptance 7 Open access: articles freely accessible online 7 Higher visibility inside the field 7 Retaining the copyright for your articleSubmit your subsequent manuscript at 7 springeropen
Al-Minshawy and El-Mazary Journal of Healthcare Case Reports 2014, eight:69 http://www.jmedicalcasereports/content/8/1/JOURNAL OF MEDICALCASE REPORTSOpen AccessCASE REPORTAn Egyptian kid with erythromelalgia responding to a brand new line of remedy: a case report and evaluation in the literatureSamir M Al-Minshawy and Abdel-Azeem M El-Mazary*AbstractIntroduction: Erythromelalgia can be a uncommon clinical syndrome characterized by episodic erythema, warmth and intense burning pain, which usually includes the extremities. For all those affected, this disorder may well result in important long-term morbidity. However, to date, no definitive therapy is offered. This case report describes an Egyptian kid with key erythromelalgia that manifested at an early age and showed partial response to therapy with cetirizine hydrochloride. This anecdotal case report might have a diagnostic value for clinicians who’ve not seen this disorder. Case presentation: A 34-month-old previously healthier right-handed Hamitic boy with out any important past medical history presented in the age of two years with episodic bilateral discomfort in his feet.Cholestyramine His mother reported related warmth and erythema localized to his feet that in no way extended beyond his ankle joints. This discomfort is triggered by exertion and/ or warm temperature exposure and is relieved by cooling measures. The diagnosis of erythromelalgia was produced based on the patient’s health-related history and a thorough physical examination during the episodes.BCI No proof of regional or systemic infection was present.PMID:23903683 Other causes for the symptoms have been excluded by a unfavorable in depth diagnostic work-up. Our patient didn’t respond to ibuprofen (15mg/kg/dose) 3 times a day but partial improvement using the oral non-sedating antihistaminic cetirizine hydrochloride (2.5mg/kg/once every day) was observed. When the kid stopped cetirizine hydrochloride for 1 month as a test, the symptoms became aggravated and were relieved when cetirizine therapy was restarted. Cetirizine hydrochloride had not previously been reported to possess this effect in young children with erythromelalgia. Conclusions: Erythromelalgia is a clinical syndrome of which the etiology, diagnosis and management are controversial. We describe a case of a 34-month-old Egyptian kid with key erythromelalgia that manifested at an early ag.